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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T20513 | IDO1-IN-1 | IDO1 inhibitor 1,2 HzBTZ,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1 | IDO |
IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. | |||
T11624 | IDO1-IN-2 | IDO | |
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity. | |||
T60499 | IDO1/TDO-IN-2 | ||
IDO1/TDO-IN-2 (Compound 1) is a potent IDO1/TDO dual inhibitor with IC50s of 0.1 and 0.07 μM, respectively. IDO1/TDO-IN-2 has the potential for cancer research[1]. | |||
T63222 | IDO1/2-IN-1 | ||
IDO1/2-IN-1 is the first potent, orally active dual IDO1/IDO2 inhibitor, exhibiting antitumor effects with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. | |||
T63651 | IDO1/2-IN-1 hydrochloride | ||
IDO1/2-IN-1 hydrochloride is the first potent dual inhibitor of IDO1 (IC50: 28 nM) and IDO2 (IC50: 144 nM) that is orally active.IDO1/2-IN-1 hydrochloride exhibits antitumor effects. | |||
T1806 | IDO-IN-7 | NLG919,Navoximod,NLG-919 analogue,GDC-0919 | Indoleamine 2,3-Dioxygenase (IDO) |
IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor. | |||
T3S1967 | (S)-Indoximod | N-ME-Tryptophan,Abrine,L-Abrine | Others , Indoleamine 2,3-Dioxygenase (IDO) |
(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse L... | |||
T61385 | IDO1/TDO-IN-1 | ||
IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhi... | |||
T37329 | PROTAC IDO1 Degrader-1 | PROTAC IDO1 Degrader-1 | |
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the... |